Potent Anticonvulsant 1H-Imidazol-5(4H)-One Derivatives with Low Neurotoxicity
نویسندگان
چکیده
منابع مشابه
Potent Anticonvulsant 1H-Imidazol-5(4H)-One Derivatives with Low Neurotoxicity
We report here the synthesis and in vivo anticonvulsant/neurotoxicity activities of a series of compounds belonging to 2-aryl-4-arylidene-1-phenyl-1H-imidazol-5(4H)-one. The scaffold is based on the commonality of 5-membered lactam ring structures as successful anticonvulsant agents. The present compounds exhibited a range of anticonvulsant activity in pentylenetetrazole (PTZ)-induced seizure t...
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ژورنال
عنوان ژورنال: Open Journal of Medicinal Chemistry
سال: 2012
ISSN: 2164-3121,2164-313X
DOI: 10.4236/ojmc.2012.22004